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Efficacy Data: Response rate: Not reported Remission rate: Not reported MADRS change: -15.0 (osavampator) vs -10.0 (placebo) at 6 weeks (Phase 2) Time to response: 2-4 weeks Source Why it might interest you: Novel mechanism (AMPA modulation), potentially faster onset, and lower risk of sexual dysfunction, weight gain, or sedation than standard antidepressants

Benefits: Reduced Harmful Chemicals: Heated tobacco produces fewer harmful chemicals associated with combustion compared to traditional cigarettes or pipes