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Discussion There was a high level of agreement to take part in the study by the families and the high rate of involvement of siblings demonstrated willingness to contribute to greater knowledge in this area

Mechanistically, riboflavin deficiency leads to diminished glutathione reductase activity, reducing the GSH/GSSG ratio and compromising redox buffering

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The progression of HT is also impacted by epigenetic modifications like miRNA levels, oxidative stress