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Physiological Rev

While GR1 encodes a cytosolic, or peroxisomal, form of the enzyme, GR2 , which contains a long N-terminal sequence, encodes a mitochondrial and chloroplastic form

The authors administered oral Dihexa to APP/PS1 transgenic mice (a standard amyloidopathy model of Alzheimers disease) and showed that brain AngIV levels were elevated relative to wild-type after Dihexa administration, that spatial learning and memory were restored on Morris water maze testing, that hippocampal neuronal density and synaptophysin protein expression were preserved, that astrocyte and microglial activation were reduced, and that pro-inflammatory cytokines (IL-1, TNF-) decreased while anti-inflammatory IL-10 increased

If youre choosing between adding MOTS-C to a GH peptide or adding a second GH peptide (compare hexarelin with ipamorelin if youre in that decision), MOTS-C is usually the cleaner pick