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Research Pichia pastoris secreted peptides crossing the blood-brain barrier and DSIP fusion peptide efficacy in PCPA-induced insomnia mouse models Mu X, Qu L, Yin L, Wang L, Liu X, Liu D (2024, October) This study developed a novel fusion peptide, DSIP-CBBBP, combining delta sleep-inducing peptide (DSIP) with a blood-brain barrier crossing peptide, produced via Pichia pastoris
However, patients enrolled in most related studies reported painful DPN resulting in sleep problems and more severe pain leading to worse sleep quality [11, 32]
May promote excretion of excess organic or fatty acids in patients with defects in fatty acid metabolism and/or specific organic acid metabolic disorders that result in accumulation of acyl-coenzyme A (acyl-CoA) esters
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