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4.2 Regulation of ferroptosis by gut microbiota metabolites 4.2.1 Short-chain fatty acids Short-chain fatty acids (SCFAs)mainly acetate, propionate, and butyratehave been shown to exert multiple beneficial effects in letrozole-induced PCOS rat models, such as improving lipid metabolism and mitigating oxidative stress and inflammation

( E ) Densitometry results showing increases in intracellular periostin (POSTN), CCL26, and iNOS following treatment with erastin ( n = 34)