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In addition, AS-IV has been found to restore the expression of p62, a sortilin protein, by reducing the levels of cystatin-C (Cyt-C) and poly (ADP-ribose) polymerase (PARP), thus correcting the autophagy imbalance in cardiomyocytes caused by DOX (Luo et al., 2021b)

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Combining delay with distraction, engaging in an activity that occupies attention during the waiting period, reduces the probability that a craving will result in drinking