2003 Oct;6(5):269-75
Maquart FX, Bellon G, Chaqour B, Wegrowski J, Patt LM, Trachy RE, Monboisse JC, Chastang F, Birembaut P, Gillery P: In vivo stimulation of connective tissue accumulation by the tripeptide-copper complex glycyl-L-histidyl-L-lysine-Cu2+ in rat experimental wounds
Several factors can reduce DAO levels or activity, including: Gut inflammation (due to infections, food intolerances, IBD, parasites) Leaky gut (increased intestinal permeability) Nutrient deficiencies (e.g., vitamin B6, vitamin C, copper, zinc) Medications (e.g., NSAIDs, antibiotics, antihistamines, antidepressants) Chronic stress Microbial imbalance (dysbiosis) Genetic polymorphisms affecting DAO gene expression Damage to the intestinal lining where DAO is produced is one of the most common contributors to low DAO activity and histamine intolerance
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