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Feeding is also controlled by brain reward systems and psychological states, which reinforce the motives for excessive eating without homeostatic value (Saper et al., Tolerance due to chronic nicotine use may potentially affect its activation of the brain reward pathway

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Similarly, 9 -THC and CB 2 agonists can suppress the differentiation of monocytes into antigen-presenting DCs which results in an inability of DCs to stimulate T cell proliferation or to promote their differentiation into functional effector/memory T cells [110]