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However, this altered cytokine environment also influences the function of organs not primarily affected by the inflammatory processes, for example, the liver

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A randomized chemoprevention trial in Finland involving of 29,133 male smokers aged 5069 years found that beta-carotene supplementation increased the risk of lung cancer compared to placebo, highlighting how antioxidant effects can be influenced by confounding lifestyle factors such as tobacco and alcohol use (Middha et al., 2019)