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Melanin index values decreased slightly after 10 weeks application of the placebo lotion (Week 0: 274.1325.82

Panel B of Figure 5 shows that the fluctuations in methionine input cause very large fluctuations in SAM but only modest fluctuations in intracellular methionine concentration, as suggested by the early methionine loading experiments of Finkelstein and co-workers [53, 54]

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