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In answer to the more direct question of how much nicotine per day is safe, a reasonable starting point might be, "How much nicotine might it take to poison someone?" The ECHA currently gives an "acute toxicity estimate" (ATE) for nicotine via the oral route to be 5 mg/kg bw [7] , meaning 5mg of nicotine for every kilogram of bodyweight of the person consuming the nicotine

Cigarette smoke modulates PGE2 and host defence against Moraxella catarrhalis infection in human airway epithelial cells

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Maternal cigarette smoking during pregnancy increases the risk of having a child with congenital digital anomaly (Man