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Molecular docking and biochemical studies indicate that luteolin interacts with estrogen receptor- (ER-) and estrogen receptor- (ER-) within their ligand-binding domains ( At the receptor level, luteolins differential binding to ER- and ER- allows it to function as a weak phytoestrogenic selective estrogen receptor modulator (SERM), displaying partial agonist activity in estrogen-deficient environments and antagonistic effects under estrogen-excess conditions ( 5.6 Integrated cross-talk and systems-level regulation The pathways described above operate as an integrated signaling network rather than isolated linear cascades

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It can be poured directly into the mouth and consumed