doi: 10.1007/s40265-019-01127-8 11 BertoliniM.RanjanA.ThompsonA.DiazP
Hussain T, Tan B, Murtaza G, Liu G, Rahu N, Kalhoro MS et al (2020) Flavonoids and type 2 diabetes: evidence of efficacy in clinical and animal studies and delivery strategies to enhance their therapeutic efficacy
"However, most peptides are designed for specific delivery methods, and using them intranasally can make absorption unpredictable." Peptide Cheat Sheet Copper Peptides (GHK-CU): Known for firming properties
Finally, a four-year, multicenter, clinical trial in 421 diabetic patients with distal symmetric sensorimotor polyneuropathy found no difference between oral administration of 600 mg/day of lipoic and placebo on the primary endpoint, a composite score that assessed neuropathic impairment of the lower limbs and nerve conduction (78)