It plays a central role in mitochondrial energy metabolism as an electron carrier in the respiratory chain (complexes I and III)
PLP is a cofactor for the synthesis of several neurotransmitters including serotonin, the catecholamines dopamine, norepinephrine, and epinephrine [critical enzyme is aromatic L-amino acid decarboxylase (AADC) which is encoded by the DDC gene and is more commonly referred to as DOPA decarboxylase], and -aminobutyric acid, GABA (critical enzyme is glutamic acid decarboxylase, GAD)
Daley, R., Maddipatla, V., Ghosh, S., Chowdhury, O., Hose, S., Zigler, J
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