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In this study, they found that both miR-148a and miR-152 are downregulated in BC cell lines due to DNA hypermethylation as compared to normal breast cells

L., Vingren, J

Ferroptosis does not require a specific pro-death signaling pathway but is triggered spontaneously when the protection of cellular membrane phospholipids from peroxidation by the metabolites and enzymes, including cysteine and glutathione peroxidase 4 (GPX4), are weakened [228, 229]

2A, compared with VRK2-KO cells downregulating the paralog genes involved in the GSH metabolic pathway, VRK2-KO cells with GCLC, GSS, and especially SLC7A11 knockdown exhibited increased ROS level, decreased GSH level and cellular viability