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(iv) glutamine polarizes macrophages to M2 phenotype [183] and, as a precursor of glutamate, can also restrain macrophages function, after glutamate-induced N-methyl-D-aspartate receptor (NMDAR) channel activation, leading to tumor development in mouse models of fibrosarcoma and hepatocellular carcinoma [184]

The reduction reaction was catalysed by PDI at room temperature, and the resulting aggregation of reduced insulin B chains was measured at 620 nm

8.3 Application of TGP in Sjogrens syndrome Sjogrens syndrome (SS) is a chronic inflammatory autoimmune disease characterized by lymphocyte infiltration of exocrine glands (Alexopoulou, 2022)