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The primary safety consideration is ensuring proper dosing relative to body weight and metabolic baseline, not interaction risk between the two compounds

The Grading of Recommendation, Assessment, Development, and Evaluation (GRADE) tool was used to assess the certainty of the evidence for the two primary biochemical outcomesserum vitamin B12 concentration increase and homocysteine reductionacross all included studies, and separately for randomised controlled trials (RCTs) and observational studies

This is the same logic behind loading protocols in many peptide therapies

However, when the blood supply to the brain is insufficient, the end result is dizziness and lightheadedness, especially when the patient stands up suddenly or exerts themselves