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Damage to nerve tissue (peripheral neuropathy), leading to pain, numbness, and weakness in extremities: These can be caused by the vitamins role in the proper functioning of the nervous system

If response at 300mcg appears minimal after two weeks, increase to 400mcg

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The treadmill speed increased by 1 km/h every min for the first 4 min, after which the workload was increased by raising the incline 1 every following min until exhaustion