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The importance of the tumour microenvironment in the progression and treatment response of CRC is well documented, with high infiltration of T-cells associated with improved prognosis (74), suggesting that in addition to tumour cell-specific effects, metformin-mediated modulation of host immunity may also underlie its radiosensitising effects

A specialized psychotherapy called CBASP (Cognitive Behavioral Analysis System of Psychotherapy), developed specifically for chronic depression, is one of the few therapies explicitly targeted to PDD