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Food Biosci 45:101469

The receptor activator of nuclear factor kappa- ligand (RANKL)/RANK pathway drives osteoclastogenesis, leading to bone erosion in 80% of untreated patients within 2 years (13)

In addition, both uremic controls and rhGH-treated uremic animals showed a significantly increased mean sclerotic index, compared to healthy rats, which was even more pronounced in rhGH-treated animals, suggesting that the beneficial effects of prolonged rhGH-treatment on kidney growth results in progressive glomerulosclerosis in rodents