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Therefore, in hyperglycemia, increased EndMT leads to excessive fibroblast activation and causes extracellular matrix protein overproduction, interstitial fibrosis, and a thicker basement membrane (143, 144)

170 These studies collectively illustrate that a wide range of phytochemicals, including terpenoids (oridonin, triptolide, atractylenolide I), flavonoids (SKN, galangin, engeletin), and phenolics (canolol), act through common and well-conserved inflammatory pathways