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In higher amounts, it interacts with the brain in a manner

Historically, the obesity pharmacotherapy literature notes early trial signals and also that development was terminated after failure to show meaningful weight loss in a larger, longer trial (as summarized in a peer-reviewed review discussing a 12-week signal and a later 24-week negative result)

The concept draws from hormesis, a biological phenomenon where low-dose exposure to a substance produces beneficial effects while higher doses might produce neutral or even counterproductive outcomes

Conventional treatment includes splinting, anti-inflammatory medications, and corticosteroid injections