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The scientific evidence on their effectiveness is still evolving, and they are not a substitute for long-term healthy habits

The mammalian sirtuins (Sirt1--Sirt7) participate in a number of cellular and physiological functions such as gene silencing, apoptosis, mitochondrial function, energy homeostasis, and longevity [237].Transgenic mice with overexpression of the sirt1 gene demonstrate decreased lipid-induced inflammation, improved glucose tolerance, and protection from hepatic steatosis when fed a high-fat diet [238]

Traditional weight loss drugs often limit their application due to systemic side effects

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