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Common injection sites include: Anterior, inferior, and posterior glenohumeral ligaments Middle glenohumeral ligament (MGHL) Posterior capsule (for posterior instability) Rotator interval region Long head of biceps anchor (if involved) By treating these areas, prolotherapy helps restore the biomechanical integrity of the joint capsule, thereby reducing: Pain Recurrent subluxation or dislocation Weakness Activity limitations Ideal Candidates for Prolotherapy Prolotherapy may be appropriate for patients who: Have residual instability or discomfort after a shoulder dislocation Show evidence of ligament laxity on physical exam Have failed to achieve stability through physical therapy alone Want to avoid surgery Have generalized ligamentous laxity or hypermobility (e.g., Ehlers-Danlos) It is often most effective in those with functional instability (ligament laxity) rather than mechanical instability from severe labral tears

Elhassan, Y

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To address the challenge of in vivo delivery of the hydrophobic erucamide molecule, we utilized organosilane-modified porous silicon nanoparticles (pSiNPs)