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In this sense, the involvement of PKC in experimental models of CIPN was also evidenced by several papers, although mechanical hyperalgesia was decreased by the treatment with PKC inhibitors such as hypericin and calphostin C (Norcini et al., 2009)

GSK3 serves as a key kinase in the hyperphosphorylation of the microtubule-associated protein tau, thereby contributing to neuronal dysfunction and degeneration [91, 92]

Consistent capital allocation The team expects each owned company to make disciplined capital allocation decisions, which can lead to higher and more consistent returns

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