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Proteasome inhibition protects bloodbrain barrier P-glycoprotein and lowers a brain levels in an Alzheimers disease model

Gastrointestinal disorders were not dependent on cagrilintide dose, with 1238 events occurring in 7 (58%) of 12 participants to 11 (92%) of 12 participants given cagrilintide 0.164.5 mg in combination with semaglutide 2.4 mg, compared with 50 events occurring in 19 (79%) of 24 pooled participants given placebo in combination with semaglutide 2.4 mg