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Even though some individuals with excess adiposity might be relatively metabolically healthy compared to others with a similar BMI, they may still be considered at risk for obesity-related primarily non-metabolic complications (e.g., osteoarthritis, gallstones, gastro-oesophageal reflux disease) 3

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Insulin and IGF-1 improve mitochondrial function in a PI-3K/Akt-dependent manner and reduce mitochondrial generation of reactive oxygen species in Huntingtons disease knock-in striatal cells

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