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Reduced Purkinje cell dendritic arborization and loss of dendritic spines in essential tremor

For EtOH-fed mice, the diet contained 2% v/v EtOH (10.8% total calories) in the first wk and the ethanol content increased weekly by 1% until reaching 5% v/v (27% total calorie)

Compared to Oral administration, whereby under 10% actually enters the blood stream, Oro-buccal administration by Oral Dispersible Film(ODF) leads to over 80% absorption directly into the systemic circulation

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