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That is the mechanistic case for the blend in one paragraph and it is exactly why the two are described as complementary rather than redundant

Excretion Pathways Limited data on combined excretion indicates: Primarily renal elimination of peptide fragments Hepatic metabolism contributes to overall clearance Copper recycling through normal physiological pathways No evidence of accumulation in chronic dosing studies (animal models) The relationship between rapid plasma clearance and prolonged biological effects represents a key area requiring further mechanistic investigation across all three components

Matsumura, S

Thus, adequate treatment for obesity is necessary, including lifestyle changes (diet adequation and physical activity) and pharmacotherapy