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Platelet-derived formulations exhibit a rich reservoir of bioactive agents and cytokines, including interleukin 1 (IL-1), transforming growth factor beta (TGF-), platelet-derived growth factor (PDGF), vascular endothelial growth factor (VEGF), epidermal growth factor (EGF), insulin-like growth factor 1 (IGF-1), hepatocyte growth factor (HGF), and basic fibroblast growth factor (-FGF)

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However, native amylin presents significant challenges for therapeutic use, including rapid enzymatic degradation, tendency to form pathological amyloid fibrils, and poor bioavailability when administered exogenously