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doi: 10.3390/toxins10040155 103

These phenotypic differences lie in single amino acid changes that greatly affect the structure and therefore binding affinity of ApoE, with ApoE3 containing Cys-112 and Arg-158, ApoE2 having Cys-112 and Cys-158, and finally ApoE4 with Arg-112 and Arg-158 (Huang and Mahley, 2014)

Curr Pharm Biotechnol 15(4):362372 Diaz A, Muoz-Arenas G, Caporal-Hernandez K, Vzquez-Roque R, Lopez-Lopez G, Kozina A, Espinosa B, Flores G, Trevio S, Guevara J (2020) Gallic acid improves recognition memory and decreases oxidative-inflammatory damage in the rat hippocampus with metabolic syndrome