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In contrast, radiation promotes cuproptosis by increasing mitochondrial copper through upregulation of the copper importer solute carrier family 31 member 1 (SLC31A1, also known as CTR1) while simultaneously depleting mtGSH, thereby shifting copper homeostasis toward toxicity 170

Basal blood cell count, urinalysis and blood chemistry including BUN, creatinine, liver function test, and fasting blood sugar were normal in the all subjects

Paeonol, the major bioactive compound in peony bark, is a natural free radical scavenger with antioxidant, anti-inflammatory, and cartilage-protective properties