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Post-surgical recovery affecting multiple tissue types, chronic widespread inflammation, and patients whose primary complaint is global stiffness and reduced range of motion that has not improved with localized treatment all fit the TB-500 indication

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This is due to the enhanced activities of antioxidant enzymes such as SOD, POD, CAT and APX, together with the increase in photosynthetic pigments such as chlorophyll a, chlorophyll b, carotenoids, and total pigments (Ibrahim et al., 2017)

The established treatment paradigm now favors starting with anabolic therapy (teriparatide or abaloparatide) and then switching to an antiresorptive (bisphosphonate or denosumab) to maintain gains