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Abbreviations ADC: Arginine decarboxylase ADI: Arginine deiminase ADI-PEG20: Pegylated arginine deiminase ALL: Acute lymphoblastic leukemia AML: Acute myeloid leukemia AOC: Aminooxetane-3-carboxylate ASL: Arginine-succinate lyase ASNS: Asparagine synthetase ASS1: Arginino-succinate synthetase ATP: Adenosine triphosphate BPTES: Bis-2-(5-phenylacetamido-1,2,4-thiadiazol-2-yl)ethyl sulfide BPTES-NP: BTPES nanoparticle B-Raf: v-raf murine sarcoma viral oncogene homolog B1 BRAFi: B-Raf inhibitor CQ: Chloroquine DFMO: D,L--difluoromethylornithine DNA: Deoxyribonucleic acid DON: 6-Diazo-5-oxo-L-norleucine E

A functional interaction between herpes simplex virus 1 glycoprotein gH/gL domains I and II and gD is defined by using alphaherpesvirus gH and gL chimeras

EJ: involved in conception/analysis, critical revision of the article, and final approval