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Pickart and colleagues used gene-signature databases to report that GHK modulates the expression of a large number of human genes including DNA-repair, antioxidant, and anti-inflammatory pathways shifting expression toward a healthier pattern

Human evidence is limited to a handful of small studies for BPC-157 and even less for the rest, long-term safety data doesnt exist, and the compounds sit in a regulatory grey zone that may shift through 2026

By integrating molecular, neuro-immune and microbial perspectives, we propose a systems-level model and highlight opportunities for precision medicine in IBS-care

Several clinical studies have linked it to improved attention, mental speed, and working memory