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Renal lipid accumulation is often observed in lysosomal storage diseases such as human Fabry disease 21

When ultraviolet light penetrates your skin, it causes lasting damage by producing free radicals

Constitutive activation of NRF2, mainly via loss-of-function mutations in the CUL3-adapter KEAP1 or gain-of-function mutations in NFE2L2 , is thought to provide a fitness advantage to tumor cells in confronting metabolic/oxidative stress resulting from dysregulated growth (DeNicola et al, 2011

In endometriosis, macrophages in the peritoneal fluid tend toward the M1 phenotype, perpetuating inflammation and allowing endometrial implants to establish and grow