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It works by inhibiting the enzyme NNMT (nicotinamide N-methyltransferase), which plays a role in energy metabolism and fat storage

Increased mucosal gene expression and luminal release of epidermal growth factor (EGF) and transforming growth factor-alpha (TGF-) as well as other growth factors were described in gastric cancer patients infected with Hp and these changes were reported to be normalized upon eradication of the bacteria from the stomach (97-100)

The finding that 88% of medications retained potency well beyond expiration dates does not apply to peptide drugs, which are inherently less stable than conventional small molecules

PMID: 28006086