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13: DeFoor MT, Dekker TJ

Improved sirtuin activation: NAD+ activates sirtuins (longevity enzymes) while glutathione protects sirtuins from oxidative inactivationmaximizing their anti-aging effects

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The findings were disappointing: Only one study showed significant lightening, and that was limited to sun-exposed areas like the face and forearms One study found that 37.5% of subjects experienced temporary improvements, but within six months after stopping treatment, only 6.2% maintained lighter skin The effects were inconsistent across different body parts and age groups Researchers concluded that glutathione is not effective enough as a skin-whitening agent because effects were limited and unsustainable What Is Vitamin C and How Does It Brighten Skin