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Future studies that will use more SIRT1 activators, such as metformin (71, 72) and SRT1720 (73), are warranted in order to elucidate further the interplay among FAO, altered NAD + /NADH ratio, SIRT1, SIRT3, and acetyltransferases, such as GCN5 (74), in regulating acetylation and activation of PGC1 along with acetylation of mitochondrial proteins

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Dietary factors , such as a diet high in nitrites (commonly found in processed foods) or excessive alcohol intake, can contribute to B12 deficiency