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Symptomatologic improvement was greater in patients younger than 6 years of age as compared to those who began supplementation at an older age, though, this study was a case series of 20 patients, further randomized controlled trials are needed

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While these can provide localized antioxidant support, they often struggle to penetrate deep enough into the dermis to influence pigment production at the cellular level

If these appear, reduce tirzepatide dose, pause 5-amino-1MQ, and increase caloric intake by 200400 kcal daily until symptoms resolve