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In the GHK-Cu complex, the copper ion coordinates with multiple binding sites: the nitrogen from the histidine imidazole side chain, the alpha-amino group of glycine, the deprotonated amide nitrogen of the glycine-histidine peptide bond, and oxygen from the lysine carboxyl group, forming a square-planar pyramid configuration

Cardiac events arising from SUN include congestive heart failure, reduction in left ventricular ejection fraction, hypertension, myocardial infarction, and thromboembolism [6, 7]

But in-office chemical peels use higher concentrations

References 1 AlbertO.Desdoits-LethimonierC.LesnL.LegrandA.GuillF.BensalahK.et al (2013)