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Pushing forward: remyelination as the new frontier in CNS diseases

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Among the most important are the degeneration of dopaminergic neurons and the loss of the substantia nigra, combined with the intracellular aggregation of -synuclein, which forms Lewy bodies and neurites [7]

Retatrutide at maximum dose achieves roughly 24-29% body weight reduction versus 15% for semaglutide and 22% for tirzepatide in comparable trial durations