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A number of studies report frequent collections of B cells (diffuse distribution, more focal aggregates or even follicle-like structures) in up to 40% of MS patients at various stages of disease (Jain and Yong, 2021)

1 Mechanistically, treatment raised the Bcl-2/Bax ratio and reduced apoptosis markers (cleaved caspase-3 and PARP) in the dermal papilla cells, elevated VEGF production, and decreased TGF-1 secretion from dermal fibroblasts

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