Because elderly patients are more likely to have decreased renal function, care should be taken in dose selection, and it may be useful to monitor renal function
Solvent A contained isopropanol/hexane/water (285:215:5, v/v/v), and solvent B contained isopropanol/hexane/water (285:215:40, v/v/v)
Additionally, the same researchers later treated 4-month-old AD model mice by gavage daily for 5 months, with 25 mg/kg SF, which significantly reduced A plaque levels in the hippocampus and cerebral cortex, improved cognition, and was shown to reduce HDAC 1 and 3 levels, suggesting its potential to counteract A-induced cytotoxicity in AD models [232]
This level of reliability in the research shows an expectation toward change in the confidence level with further research (Nehra, et al., 2015)