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Importantly, among children with the AG + AA genotype for rs6970396 Se metabolizing indolethylamine N-methyltransferase gene (INMT), an inverted U-shaped association between Se and neuropsychological development was identified, albeit a descending curve was indicated for the GG genotype [28]

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These genes affect pathways involving: methylation folate metabolism redox balance the transsulfuration pathway glutathione production When certain variants occur in a homozygous state , they can significantly increase a persons baseline homocysteine levels