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Introduction Sulfur is an essential element that is incorporated into various cellular metabolites and used for multiple metabolic processes in fungi, including the proteogenic amino acids cysteine (Cys) and methionine (Met), oxidative stress defense [glutathione (GSH) and ergothioneine (EGT)], methylation [ S -adenosylmethionine (SAM)], epipolythiodioxopiperazine (ETP) toxin biosynthesis (e.g., gliotoxin) and iron metabolism (FeS clusters) (Struck et al., 2012
The molecular and cellular effects reported in studies vary significantly depending on the experimental model, peptide concentration, exposure time, and methodological conditions
[DOI] [PubMed] [Google Scholar] Kim SK, Woodcroft KJ, Novak RF