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Graphical Abstract Keywords Hyperuricemia, Microbiota, Physical activity, Caveolae, Uric acid metabolism, Cardiovascular diseases, Metabolic syndrome Introduction Hyperuricemia (HU), a metabolic disorder characterized by elevated levels of uric acid (UA) in the bloodstream, is a significant global health concern

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Berberine: Berberine has been shown to decrease LDL cholesterol levels as well as Lp(a) levels a little bit

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Goat Anti-Mouse IgG H&L (iFluor 488, HA1125) was used as the secondary antibody at 1/1,000 dilution

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Indeed, transgenic mice overexpressing SORLA exhibit decreased A concentrations in brain (Slotte, 1999

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