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Research into the regulatory pathways of ferroptosis has identified several defense systems with distinct subcellular localizations, including Solute Carrier Family 7 Member 11 (SLC7A11, an antiporter that imports cystine for glutathione synthesis)-glutathione (GSH)-glutathione peroxidase 4 (GPX4), NAD(P)H-FSP1-CoQ, GCH1-BH4-DHFR, sex hormone-MBOAT1/2 and mitochondrial-localized dihydroorotate dehydrogenase (DHODH)-CoQH2 (30)

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While stress alone may not directly cause cysts, it can be a significant contributing factorespecially when combined with other underlying issues