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A 2023 review in Frontiers in Physiology noted that mitochondrial-derived peptides like MOTS-c represent a functionally separate class from growth-hormone-axis compounds such as Tesamorelin underscoring why comparison, rather than substitution, is the right framework for evaluating them

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One study in the The Journal of Allergy and Clinical Immunology found that some injected forms of B vitamins at higher doses, like B12, can be linked with an allergic reaction