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It could also impede cytokine and chemokine release like TNF-, IL-1, IL-6, and MCP-1 in macrophages, monocytes, and mastocytes, but no clinical improvement was observed in RA patients [84, 85]

Copper is an essential trace mineral involved in: Collagen synthesis Elastin formation Antioxidant defense Tissue remodeling Blood vessel formation Cellular repair mechanisms GHK-Cu acts as a carrier and signaling peptide that helps regulate tissue repair and cellular communication

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10.1016/0006-3002(54)90241-3 278 HvidtA.Linderstrom-LangK